I currently am an undergraduate Biomedical Engineering student here at Arizona State University. Post-baccalaureate, I aim to purse a Ph.D in Bioengineering in the hopes of developing imaging techniques for highlighting abnormalities of the brain associated with aging—especially resulting from neurodegenerative disease. My current research in the ProBE Lab involves co-registration of hypoxia-enhanced MR images with Pimonidazole-stained images to test the efficacy of a novel hypoxia-binding contrast agent, GdDO3NI. We hope to use this agent as a tool for imaging hypoxia in-vivo for use as a diagnostic and prognostic tool. This would allow for more efficient, non-invasive diagnosis of cancer, as well as potential for tracking the effectiveness of various cancer treatments over time by tracking tumor-hypoxia.
Luke is a current senior at Arizona State University studying biomedical engineering. In conjunction Fulton Undergraduate Research Initiative, he has been working on an honors thesis project centered on creating a graphical user interface (GUI) for compressed sensing magnetic resonance spectroscopy (MRSI). This GUI aims to be able to integrate various scanner types into a single computing platform that can perform both clinical and preclinical analysis. He hopes that this project will improve how researchers and clinicians use compressed sensing MRSI in the future.
I am an undergraduate researcher with the plan of obtaining both my bachelor’s and master’s degrees in biomedical engineering through the 4+1 accelerated program. After receiving my degrees at ASU, I plan on potentially continuing my education and pursuing a Ph.D. in cancer biology. The purpose of my current research is to incorporate a carbohydrate glass structure within a multicellular spheroid in order to simulate tumor vasculature for in vitro cells and study tumor hypoxia. Tumor hypoxia creates a demanding microenvironment and it is a contributing factor to tumor aggression, often resulting in an increase of metastasis, chemoresistance, radioresistance, and even anticancer drug resistance. Thus it is important to study tumor hypoxia, as it can provide information on the type of treatment regime most effective for killing cancer cells.
I grew up near Minneapolis, MN, where I attended Minnetonka HS and achieved the honor of Eagle Scout with the Boy Scouts of America. I am on track to graduate with my Undergraduate degree in Biomedical Engineering as part of Barrett, The Honors College in May 2017. Additionally, I am a part of the 4+1 program at ASU, and am set to graduate with a Graduate degree in Biomedical Engineering in May 2018. My current research in ProBE involves the creation of radio frequency probes for imaging mesoscale tumor spheroids, and the evaluation of the efficacy of GdDO3NI, a gadolinium-based hypoxia marker, for studying the distribution of hypoxia in multicellular tumor spheroids. The ultimate purpose of this is to find the best incubation protocol such that high resolution images of the 3D spatial variations of hypoxia can be obtained and analyzed.
I am currently an undergraduate student studying Biomedical Engineering and Pre-Medicine at Arizona State University. I plan to pursue a M.D after graduation. I was raised in Gilbert, Arizona and always had a passion for medical research. Currently, my research is centered around nano probes that are designed to report oxygenation levels in tumor tissue. These nanoparticles are siloxane based and loaded with Pimonidazole, a novel hypoxia marker. The ability to report oxygenation levels in a tumor is critical to therapy in that tumors that are hypoxic (lack oxygen) are significantly harder to treat. Therapies can be tailored with this knowledge in mind and allow for much more effective treatment.