I am a current undergraduate senior who is simultaneously obtaining a B.S.E. and M.S. in Biomedical Engineering through the 4+1 program. I am also minoring in Mathematics at the College of Liberal Arts & Sciences. I have also been accepted as part of the Fulton Undergraduate Research Initiative (FURI). Within the ProBE lab, I have concurrently been involved in two research projects: (1) creating a 3D in vitro model that allows quantitative mapping of the pO2 distribution within a 3D cell culture with MRI. In-silico results of the O2 sensitive 3D-MR scaffold (O2S3DMRS) are obtained through COMSOL Multiphysics under parameters similar to that of the real O2S3DMRS. The MRI oximetry technique, “Proton Imaging of Siloxanes, to map Tissue Oxygenation Levels (PISTOL)”, was developed by our lab and will be used to analyze images of the pO2 present in the O2S3DMRS. This allows for more in depth hypoxia research due to monitoring the dynamic pO2 profile within the tissue and providing insights into the cellular responses of hypoxia while assessing other reliable MR imaging agents. (2) Measuring cellular oximetry using Fluorescence Lifetime Imaging Microscopy (FLIM) with use of pO2 nanoprobes.
Umu Salamata Jalloh
I am currently a 3+1+1 IADP MasterCard Foundation KNUST-ASU Scholar. I just finished my undergraduate degree in Biomedical Engineering and will be starting my masters degree in Fall 2021. My current research in ProBE Lab involves Analysis of Data Collected for Quantitative Mapping of Brain Tissue Oxygenation around neural interfaces. This experiment uses computational modeling in conjunction with the “proton imaging of siloxanes, to map tissue oxygenation levels (PISTOL)” technique (developed in ProBE Lab) to perform pO2 mapping on the implant sites of neuro-sensors, as well as three-dimensional (3D) cell culture models, to obtain a quantitative spatiotemporal pO2 map within the tissue. I aim to analyze data that is used to develop a novel neural interface to measure both neural activity and the local pO2 of the recording site and also to generate a calibration curve that enables researchers to relate the tissue oxygenation and R1, to provide a standard spatial mapping of the dynamic changes in pO2 levels around the implants over time.
I am currently an undergraduate studying Biomedical Engineering here at Arizona State University. I have experience in bioinformatics, data analysis, and cloud computing and enjoy applying computer science to biomedical engineering research. After graduation, I hope to pursue a career in data analytics and computer programming in the biomedical engineering industry, with a focus on medical imaging and improving the imaging process through the development of software. My research in the ProBE lab currently focuses on processing and correcting data in time and frequency domains through the application of filters, transforms, and other image processing techniques.